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06/10/2025Mesotherapy and PRP Treatment: Which is More Effective for Your Skin?
The world of medical aesthetics offers ever-evolving, innovative treatments to rejuvenate and revitalize the skin and hair without surgery. Among these treatments, there are two important names that stand out with their popularity and effectiveness: Mesotherapy and PRP (Platelet Rich Plasma). These methods, both based on injections and supporting the health of the skin and hair follicles from the inside, are often confused with each other or one wonders which one is "better".
Mesotherapy and PRP Treatment: Which is More Effective for Your Skin?
In reality, these two treatments are not rivals, but powerful allies that work through different mechanisms and serve different purposes, sometimes even complementing each other. As Dr. Melis Ülger, Istanbul, Kadikoy‘In this guide, I would like to explain the differences between these two treatments, which one is more effective in which situation and how to make the best choice for you.
Two Powerful Treatments, One Goal: Skin Rejuvenation
The main goal of both treatments is to repair, revitalize and rejuvenate skin and hair follicles that have been weakened by aging, environmental factors or genetics. However, the methods they use to achieve this goal are completely different. We can think of one as “providing the skin with a ready-made feast from the outside” and the other as “enabling the skin to prepare its own feast by running its own kitchen”.
What is Mesotherapy? External Skin Support
Mesotherapy, As the name suggests, it is a treatment method targeted at the “mesoderm”, the middle layer of the skin.
Content: Personalized Vitamin and Nutrient Cocktail
Mesotherapy is based on a “cocktail” that is specially prepared according to the current needs of the skin or hair follicles. This cocktail usually contains the following: Hyaluronic acid, vitamins C, A, E, minerals such as zinc, selenium, amino acids and peptides. This mixture contains ready-made nutrients, prepared externally, which are essential for the health of the skin.
Mechanism of Action Skin Nourishment and Revitalization
This customized cocktail is delivered directly under the skin through microinjections. In this way, these precious ingredients, which are difficult to reach through the bloodstream or impossible to penetrate with creams applied on the surface, are made directly available to the cells. The mechanism of action is based on nourishing, moisturizing, brightening and revitalizing the skin. It replenishes the skin's missing vitamins, boosts its antioxidant capacity and, with hyaluronic acid, provides instant moisture and radiance.
What is PRP (Platelet Rich Plasma)? The Body's Own Healing Power
PRP stands for “Platelet Rich Plasma” and stands for “platelet-rich plasma”. This treatment is completely autologous, that is, it is a method obtained from the person's own blood.
Content: Growth Factors from Your Own Blood
In PRP treatment, a small amount of blood from the patient is spun at high speed in a special centrifuge device. This process separates the components of the blood and allows us to obtain a portion of plasma with a high concentration of clotting cells called platelets. This plasma contains a much higher concentration of platelets than in normal blood (usually 3-5 times) and hundreds of valuable “growth factors” stored in these platelets.
Mechanism of Action: Skin Repair and Restructuring
This platelet-rich plasma is returned to the skin with microinjections, just like mesotherapy. However, the mechanism of action here is different. The injected growth factors send a “damage, start repairing!” signal to the skin. This signal activates stem cells in the area, stimulates fibroblast cells, triggers the skin to produce its own collagen and elastin and supports the formation of new blood vessels. The basic mechanism of PRP is not to feed the skin from the outside, but to activate the body's potential for self-repair and reconstruction.
Main Differences: Mesotherapy vs. PRP
- Source: Mesotherapy uses vitamins and nutrients prepared in a laboratory (exogenous). PRP uses the person's own blood (internal/autologous).
- Objective: The primary purpose of mesotherapy is to nourish, moisturize and revitalize the skin. The primary goal of PRP is to restructure the skin by triggering its own repair mechanisms.
- Impact Speed: The effects of mesotherapy, such as moisture and brightness, are usually seen more quickly. The collagen production triggering effect of PRP is longer term and it may take several months for the full results to appear.
Which one should be preferred in which situation?
This is the most important point where the treatment is personalized. The answer to the question “Which is more effective?” depends on what your skin or hair needs.
Facial Rejuvenation (Mesolifting vs. PRP)
If your skin looks dull, dehydrated and lifeless, you want an instant shine and glow effect, Mesotherapy (Mesolifting) is often a faster and more effective start. If your skin has structural problems such as loss of elasticity, fine lines, acne scars and you want to make a long-term collagen investment, PRP is a stronger option.
Hair Loss Treatment (Hair Mesotherapy vs. Hair PRP)
Both are extremely effective in hair loss. If there is a reason such as vitamin/mineral deficiency underlying the hair loss, Hair Mesotherapy it makes a lot of sense to give these deficiencies directly to the root. If the loss is genetic or age-related and the aim is to revitalize weakened, dormant roots, PRP‘The growth factors contained in the 's may produce a stronger stimulatory effect.
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Stronger Together: Mesotherapy and PRP Combination
The most successful results in modern medical aesthetics are usually achieved by combining or alternating these two treatments. For example, while triggering the main repair mechanisms of the skin with PRP in one session, we can support this repair process by giving the raw materials (vitamins, amino acids) needed by the skin with Mesotherapy in the next session. This is like putting both workers (PRP) and cement and bricks (Mesotherapy) on the field at the same time in a construction project. This synergistic approach increases the effectiveness of both treatments.
How Do We Determine the Special Protocol for You in Our Clinic in Kadikoy?
Kadikoy‘At our clinic in Istanbul, we never expect the patient to answer the question of Mesotherapy or PRP on his/her own. The process starts with a detailed skin or hair analysis with you. By evaluating the source of your problem, the structure of your skin and your expectations, we create the most suitable treatment protocol together. Sometimes we start the journey with Mesotherapy and continue with PRP after saturating the skin. Sometimes we draw up a combined plan right from the start. About these treatments, Institutions like Johns Hopkins Medicine also offers informative resources on the potential benefits of PRP.
Ultimately, the “more effective” treatment is the one that is planned correctly for you. Your most important guide in making this decision is your physician, who can explain both methods to you on a scientific basis and draw a road map according to your personal needs.
Contact Now for a Holistic Approach to Your Health
As Dr. Melis Ülger Clinic, we closely follow current methods and reliability in mesotherapy and PRP treatments. We are with you to achieve the most accurate and natural results for your skin. We offer effective and healthy solutions with customized protocols. For more information and questions you can contact us.
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